Doose syndrome: investigations

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Doose syndrome: investigations. This is normal at the onset. Fully referenced neurology checklist.

Electroencephalogram (EEG)

  • This is normal at the onset
  • It later shows synchronous spike wave and wave-multiple spike complexes
  • There is background slowing with parietal theta waves
  • The posterior background rhythms are normal
  • The sleep architecture is normal

Magnetic resonance imaging (MRI) brain

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Synonym

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References

  1. Kelley SA, Kossoff EH. Doose syndrome (myoclonic-astatic epilepsy): 40 years of progress. Dev Med Child Neurol 2010; 52:988-993. 
  2. Kural Z, Ozer AF. Epileptic encephalopathies in adults and childhood. Epilepsy Res Treat 2012; 2012:205131.
  3. Oguni H, Fukuyama Y, Tanaka T, et al. Myoclonic-astatic epilepsy of early childhood-clinical and EEG analysis of myoclonic-astatic seizures, and discussions on the nosology of the syndrome. Brain Dev 2001; 23:757-764.
  4. Oguni H, Fukuyama Y, Imaizumi Y, Uehara T. Video-EEG analysis of drop seizures in myoclonic astatic epilepsy of early childhood (Doose syndrome). Epilepsia 1992; 33:805-813.

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