Diabetic neuropathy: treatment
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Diabetic neuropathy: treatment. Tricyclics, Serotonin and norepinephrine reuptake inhibitors (SNRIs), Gabapentinoids. Fully referenced neurology checklist.
Level B evidence
- Tricyclics
- Serotonin and norepinephrine reuptake inhibitors (SNRIs)
- Gabapentinoids
- Sodium channel blockers
Level C evidence
Locked: subscribe to see this section.
Insufficient evidence
Locked: subscribe to see this section.
Contraindicated drugs
Locked: subscribe to see this section.
Non-drug treatments
Locked: subscribe to see this section.
Investigational treatments
Locked: subscribe to see this section.
General recommendations
Locked: subscribe to see this section.
References
- Price R, Smith D, Franklin G, et al. Oral and topical treatment of painful diabetic polyneuropathy: practice guideline update summary: report of the AAN Guideline Subcommittee. Neurology 2022; 98:31-43.
- Bril V. Treatments of diabetic neuropathy. J Peripher Nerv Syst 2012; 17(Suppl):22-27.
- Xu L, Sun Z, Casserly E, Nasr C, Cheng J, Xu J. Advances in interventional therapies for painful diabetic neuropathy: a systematic review. Anesth Analg 2022; 134:1215-1228.
- D'Souza RS, Langford B, Dombovy-Johnson M, Abd-Elsayed A. Neuromodulation interventions for the treatment of painful diabetic neuropathy: a systematic review. Curr Pain Headache Rep 2022; 26:365-377.
- Reynolds EL, Russman D, Baskozos G, Eid S, Feldman EL, Bennett DLH, Callaghan BC. Physical activity decreases the likelihood of peripheral neuropathy in persons with diabetes. JNNP 2026; 97:464-468.
- And 1 more. Subscribe to see the full list
