Delayed post-hypoxic leukoencephalopathy (DPHL)
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Delayed post-hypoxic leukoencephalopathy (DPHL). This is a demyelinating syndrome. Fully referenced neurology checklist.
Pathogenesis
- This is a demyelinating syndrome
- It follows a period of prolonged cerebral hypoxia
Causes
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Predisposing factors
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Clinical features
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Magnetic resonance imaging (MRI) brain: features
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Pathology: features
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References
- Shprecher D, Mehta L. The syndrome of delayed post-hypoxic leukoencephalopathy. NeuroRehabilitation 2010; 26:65-72.
- Nzwalo H, Sá F, Cordeiro I, Ferreira F, Basílio C. Delayed hypoxic-ischemic leukoencephalopathy. BMJ Case Rep 2011; pii: bcr0620114344.
- Katyal N, Narula N, George P, Nattanamai P, Newey CR, Beary JM. Delayed post-hypoxic leukoencephalopathy: a case series and review of the literature. Cureus 2018; 10:e2481.
- Molloy S, Soh C, Williams TL. Reversible delayed posthypoxic leukoencephalopathy. Am J Neuroradiol 2006; 27:1763-1765.
- Aljarallah S, Al-Hussain F. Acute fatal posthypoxic leukoencephalopathy following benzodiazepine overdose: a case report and review of the literature. BMC Neurol 2015; 15:69.
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