Cytotoxic lesions of the corpus callosum (CLOCC): clinical and radiological features

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Cytotoxic lesions of the corpus callosum (CLOCC): clinical and radiological features. Cytokine cascade activation. Fully referenced neurology checklist.

Possible pathogenetic mechanisms

  • Cytokine cascade activation
  • Blood–brain barrier leakage
  • Glutamate toxicity

Clinical features

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Magnetic resonance imaging (MRI) features

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Synonyms

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References

  1. Scoppettuolo P, Sinkunaite L, Topciu MF, Schulz J. Cytotoxic lesions of the corpus callosum during the course of ketotic hyperglycemia revealing type I diabetes: a case report. SAGE Open Med Case Rep 2023; 11:2050313X231172338.
  2. Elkhaled W, Ben Abid F, Akhtar N, Abukamar MR, Ibrahim WH. A 23-year-old man with SARS-CoV-2 infection who presented with auditory hallucinations and imaging findings of cytotoxic lesions of the corpus callosum (CLOCC). Am J Case Rep 2020; 21:e928798.
  3. Doherty MJ, Jayadev S, Watson NF, et al. Clinical implications of splenium magnetic resonance imaging signal changes. Arch Neurol 2005; 62: 433–437.
  4. Sousa A, Silva TM, Conceição C, Vieira JP, Gouveia C, Varandas L. Cerebral malaria and cytotoxic lesions of the corpus callosum. Pediatr Infect Dis J 2023; 42:e358-e359.
  5. Garcia-Monco JC, Cortina IE, Ferreira E, et al. Reversible splenial lesion syndrome (RESLES): what's in a name? J Neuroimaging 2011; 21:e1-e14.
  6. And 3 more. Subscribe to see the full list

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