Cryoglobulinaemic vasculitis (CryoVas): clinical features
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Cryoglobulinaemic vasculitis (CryoVas): clinical features. Meltzer’s triad, Fatigue, Raynaud's phenomenon. Fully referenced neurology checklist.
Systemic features
- Meltzer’s triad
- Fatigue
- Raynaud's phenomenon
- Acrocyanosis
- Gangrene
- Cold-induced urticaria
- Livedo reticularis
Renal features
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Gastrointestinal features
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Neurological features: central
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Neurological features: peripheral
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Respiratory features
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Cardiac features
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Dermatological features
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Endocrine features
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Other features
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Differential diagnosis
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Complications
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References
- Retamozo S, Díaz-Lagares C, Bosch X, et al. Life-threatening cryoglobulinemic patients with hepatitis C: clinical description and outcome of 279 patients. Medicine (Baltimore) 2013; 92:273-284.
- German A, Grotemeyer A, Rothhammer V, Doerfler A, Winkler J, Regensburger M. Pearls & Oy-sters: Reversible leukoencephalopathy and Parkinsonism due to CNS involvement in cryoglobulinemia. Neurology 2026; 106:e214622.
- Feldman L, Dhamne M, Li Y. Neurologic manifestations associated with cryoglobulinemia: A single center experience. J Neurol Sci 2019; 398:121-127.
- Thaunat O, Aaron L, Desbene C, et al. Type III cryoglobulinemia complicated by renal cortical necrosis. Am J Kidney Dis 2005; 45:e79-e81.
- Feldman L, Dhamne M, Li Y. Neurologic manifestations associated with cryoglobulinemia: a single center experience. J Neurol Sci 2019; 398:121-127.
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