CLIPPERS: pathology and diagnostic criteria
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
CLIPPERS: pathology and diagnostic criteria. There is predominantly a perivascular lymphocytic infiltration. Fully referenced neurology checklist.
Major neuropathological features
- There is predominantly a perivascular lymphocytic infiltration
- This is made up mostly of CD3-positive T-lymphocytes
- There is associated mild B-lymphocyte infiltration
- There is moderate macrophage infiltration
Other neuropathological features
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Clinical diagnostic criteria
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Radiological diagnostic criteria
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Acronym
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References
- Pittock SJ, Debruyne J, Krecke KN, et al. Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS). Brain 2010; 133:2626-2634.
- Simon NG, Parratt JD, Barnett MH, et al. Expanding the clinical, radiological and neuropathological phenotype of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS). JNNP 2012; 83:15-22.
- Tobin WO, Guo Y, Krecke KN, et al. Diagnostic criteria for chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS). Brain 2017; 140:2415-2425.
