CLIPPERS: clinical features

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

CLIPPERS: clinical features. Episodic diplopia, Facial paraesthesias, Gait ataxia, Diplopia, Dizziness. Fully referenced neurology checklist.

Brainstem features

  • Episodic diplopia
  • Facial paraesthesias
  • Gait ataxia
  • Diplopia
  • Dizziness

Movement disorders

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Other neurological features

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Unusual presentations

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Reported associations

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Neuroinflammatory differential diagnoses

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Other differential diagnoses

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Acronym

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References

  1. Tobin WO, Guo Y, Krecke KN, et al. Diagnostic criteria for chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS). Brain 2017; 140:2415-2425.
  2. Pittock SJ, Debruyne J, Krecke KN, et al. Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS). Brain 2010; 133:2626-2634.
  3. El Harras Y, Choayb S, Berrada K, et al. CLIPPERS manifesting with dizziness: recognizable and treatable. SAGE Open Med Case Rep 2023; 11:2050313X231177168.
  4. Ha AD, Parratt JD, Babu S, et al. Movement disorders associated with CLIPPERS. Mov Disord 2014; 29:148-150.
  5. Song B, Gao Y, Fang H, Li P, Li Y, Xu Y. Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids with lesions distributed predominantly in spinal cord. Brain 2015; 138:e397.
  6. And 33 more. Subscribe to see the full list

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