CIDP treatment: IVIg
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
CIDP treatment: IVIg. This is usually used as second line treatment after steroids. Fully referenced neurology checklist.
Benefits
- This is usually used as second line treatment after steroids
- It has a similar benefit as plasma exchange (PE)
- It is effective in 50% of steroid non-responders
Indications for first line use of IVIg: ahead of steroids
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Protocol
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Response
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Predictors of poor response
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Predictors of good response
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Subcutaneous immunoglobulins (SCIG)
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Maintenance therapy
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Treatment related fluctuations (TRFs)
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IVIg withdrawal
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Acronym
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References
- Ripellino P, Fleetwood T, Cantello R, Comi C. Treatment of chronic inflammatory demyelinating polyneuropathy: from molecular bases to practical considerations. Autoimmune Dis 2014; 2014:201657.
- Eftimov F, Vermeulen M, van Doorn PA, et al. Long-term remission of CIDP after pulsed dexamethasone or short-term prednisone treatment. Neurology 2012; 78:1079-1084.
- van Schaik IN, Eftimov F, van Doorn PA, et al. Pulsed high-dose dexamethasone versus standard prednisolone treatment for chronic inflammatory demyelinating polyradiculoneuropathy (PREDICT study): a double-blind, randomised, controlled trial. Lancet Neurol 2010; 9:245-253.
- Kuitwaard K, Hahn AF, Vermeulen M, Venance SL, van Doorn PA. Intravenous immunoglobulin response in treatment-naïve chronic inflammatory demyelinating polyradiculoneuropathy. JNNP 2015; 86:1331-1336.
- Lehmann HC, Burke D, Kuwabara S. Chronic inflammatory demyelinating polyneuropathy: update on diagnosis, immunopathogenesis and treatment. JNNP 2019; 90:981-987.
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