Chronic traumatic encephalopathy (CTE): pathology and imaging
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Chronic traumatic encephalopathy (CTE): pathology and imaging. Hyperphosphorylated tau. Fully referenced neurology checklist.
Pathological features
- Hyperphosphorylated tau
- Astrocytic and neurofibrillary tangles
- Neurites
- TDP-43 may be positive
- β amyloid may be positive
Magnetic resonance imaging (MRI) features
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References
- Saulle M, Greenwald BD. Chronic traumatic encephalopathy: a review. Rehabil Res Pract 2012; 2012:816069.
- McKee AC, Cantu RC, Nowinski CJ, et al. Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury. J Neuropathol Exp Neurol 2009; 68:709-735.
- Baugh CM, Stamm JM, Riley DO, et al. Chronic traumatic encephalopathy: neurodegeneration following repetitive concussive and subconcussive brain trauma. Brain Imaging Behav 2012; 6:244-254.
- McKee AC, Stern RA, Nowinski CJ, et al. The spectrum of disease in chronic traumatic encephalopathy. Brain 2013; 136:43-64.
