Cerebrospinal fluid (CSF): protein
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Cerebrospinal fluid (CSF): protein. Site of CSF collection, Technique of collection, Examining laboratory. Fully referenced neurology checklist.
Determinants of CSF protein concentration
- Patient’s age: it is higher in neonates and in those >60 years
- Site of CSF collection
- Technique of collection
- Examining laboratory
Causes of mildly raised CSF protein (45-75mg/dL)
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Causes of moderately raised CSF protein (75-500mg/dL)
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Causes of severely raised CSF protein (>500mg/dL)
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Causes of low CSF protein
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CSF biomarkers of bacterial meningitis with traumatic LP
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References
- Bhidayasiri R, Waters MF, Giza CC. Neurological differential diagnosis. A prioritized approach. Blackwell publishing Massachussetts 2005 p491-492.
- Diesenhammer F, Bartos A, Egg R, et al. Guidelines on routine cerebrospinal fluid analysis. Report from an EFNS task force. Eur J Neurol 2006; 13:913-922.
- Seehusen DA, Reeves MM, Fomin DA. Cerebrospinal fluid analysis. Am Fam Physician 2003; 68:1103-1108.
- Nazir M, Wani WA, Kawoosa K, et al. The diagnostic dilemma of traumatic lumbar puncture: current standing of cerebrospinal fluid leukocyte corrections and our experience with cerebrospinal fluid biomarkers. J Child Neurol 2018; 33:441-448.
- Zhang G, Yang C, Kang X, Gao Z, Wan H, Liu Y. The combination of cerebrospinal fluid procalcitonin, lactate, interleukin-8 and interleukin-10 concentrations for the diagnosis of postneurosurgical bacterial meningitis: a prospective study. Ann Clin Biochem 2018; doi: 10.1177/0004563218794729 (Epub ahead of print).
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