Cerebral palsy (CP): differential diagnosis
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Cerebral palsy (CP): differential diagnosis. 3-Methylglutaconic aciduria, Adrenoleukodystrophy (ALD). Fully referenced neurology checklist.
Differentials of predominantly spastic CP
- 3-Methylglutaconic aciduria
- Adrenoleukodystrophy (ALD)
- Adrenomyeloneuropathy (AMN)
- Arginase deficiency
- Biotidinase deficiency
- COL4A1 deficiency
- Glutaric aciduria type 1
- Hereditary spastic paraparesis (HSP)
- Metachromatic leukodystrophy (MLD)
- Molybdenum cofactor deficiency
- Neuronal ceroid lipofuscinosis
- Sulfite oxidase deficiency
- Uner Tan syndrome: ITPR1 gene mutation
Differentials of predominantly dyskinetic CP
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Differentials of predominantly ataxic CP
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Differentials of predominantly weakness CP
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References
- Hakami WS, Hundallah KJ, Tabarki BM. Metabolic and genetic disorders mimicking cerebral palsy. Neurosciences (Riyadh) 2019; 24:155-163.
- Gupta R, Appleton RE. Cerebral palsy: not always what it seems. Arch Dis Child 2001; 85:356-360.
- Pantaleoni C, D'Arrigo S, D'Incerti L, Rimoldi M, Riva D. A case of 3-methylglutaconic aciduria misdiagnosed as cerebral palsy. Pediatr Neurol 2000; 23:442-444.
- Straussberg R, Brand N, Gadoth N. 3-Methyl glutaconic aciduria in Iraqi Jewish children may be misdiagnosed as cerebral palsy. Neuropediatrics 1998; 29:54-56.
- Suchowersky O, Ashtiani S, Au PB, McLeod S, Estiar MA, Gan-Or Z, Rouleau GA. Hereditary spastic paraplegia initially diagnosed as cerebral palsy. Clin Park Relat Disord 2021; 5:100114.
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