Carbamazepine: side effects
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Carbamazepine: side effects. Spina bifida, Cardiac malformations, Dental anomalies. Fully referenced neurology checklist.
Teratogenic side effects
- Dysmorphic appearance: doll-like appearance with full cheeks and a small chin
- Spina bifida
- Cardiac malformations
- Dental anomalies
Steven-Johnson syndrome: risk markers
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DRESS syndrome
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Hyponatraemia
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Neurological side effects
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Haematological side effects
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Cardiac side effects
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Systemic side effects
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Carbamazepine resistance
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References
- Kini U, Adab N, Vinten J, Fryer A, Clayton-Smith J; Liverpool and Manchester Neurodevelopmental Study Group. Dysmorphic features: an important clue to the diagnosis and severity of fetal anticonvulsant syndromes. Arch Dis Child Fetal Neonatal Ed 2006; 91:F90-F95.
- Jentink J, Dolk H, Loane MA, et al; EUROCAT Antiepileptic Study Working Group. Intrauterine exposure to carbamazepine and specific congenital malformations: systematic review and case-control study. BMJ 2010; 341:c6581.
- Verrotti A, Mencaroni E, Castagnino M, Zaccara G. Foetal safety of old and new antiepileptic drugs. Expert Opin Drug Saf 2015; 14:1563-1571.
- Tomson T, Xue H, Battino D. Major congenital malformations in children of women with epilepsy. Seizure 2015; 28:46-50.
- Güveli BT, Rosti RÖ, Güzeltaş A, et al. Teratogenicity of antiepileptic drugs. Clin Psychopharmacol Neurosci 2017; 15:19-27.
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