Carbamazepine: clinical use
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Carbamazepine: clinical use. Carbamazepine is a voltage gated sodium channel inhibitor. Fully referenced neurology checklist.
Mode of action and indication
- Carbamazepine is a voltage gated sodium channel inhibitor
- It is indicated for partial and generalised seizures
Dosing
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Full blood count monitoring of Carbamazepine
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Long-term monitoring of Carbamazepine (2-5 yearly)
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Drug which reduce Carbamazepine blood levels
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Drug which increase Carbamazepine blood levels
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Drugs whose levels are reduced by Carbamazepine
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References
- Ambrósio AF, Soares-Da-Silva P, Carvalho CM, Carvalho AP. Mechanisms of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-024. Neurochem Res 2002; 27:121-130.
- Mantegazza M, Curia G, Biagini G, Ragsdale DS, Avoli M. Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders. Lancet Neurol 2010; 9:413-424.
- Porter RJ. How to initiate and maintain carbamazepine therapy in children and adults. Epilepsia 1987; 28(Suppl 3):S59-S63.
- Goldenberg MM. Overview of drugs used for epilepsy and seizures: etiology, diagnosis, and treatment. P T 2010; 35:392-415.
- Powell G, Saunders M, Marson AG. Immediate-release versus controlled-release carbamazepine in the treatment of epilepsy. Cochrane Database Syst Rev 2014; 2:CD007124.
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