Anti-SEZ6L2 cerebellar syndrome
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Anti-SEZ6L2 cerebellar syndrome. Cerebellar dysfunction, Cognitive impairment, Movement disorders. Fully referenced neurology checklist.
Clinical features
- Cerebellar dysfunction
- Cognitive impairment
- Movement disorders
- Psychiatric symptoms
- Other features
Magnetic resonance imaging (MRI) brain
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Positron emission tomography (PET) scan
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Cerebrospinal fluid (CSF) analysis
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Other investigations
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Treatment
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Acronym
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References
- Habicht JL, Cammá G, Wurdack K, Teegen B, Prüss H, Finke C. Clinical spectrum of anti-SEZ6L2 syndrome: a case report with brain volumetry and systematic literature review. Neurol Neuroimmunol Neuroinflamm 2026; 13:e200614.
- Hoshina Y, Kobayashi G, Reda H. Clinical spectrum of SEZ6L2 autoimmunity: a case report and systematic review. Cerebellum 2026; 25:51.
- Kather A, Holtbernd F, Brunkhorst R, et al. Anti-SEZ6L2 antibodies in paraneoplastic cerebellar syndrome: case report and review of the literature. Neurol Res Pract 2022; 4:54.
- Mehdiyeva A, Hietaharju A, Sipilä J. SEZ6L2 antibody-associated cerebellar ataxia responsive to sequential immunotherapy. Neurol Neuroimmunol Neuroinflamm 2022; 9:e1131.
- Gao Y, Duan R. Anti-Sez6L2 antibody-associated autoimmune cerebellar ataxia: a rare case with implications of rituximab therapy. Neurol Sci 2026; 47:436.
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