Anti neurochondrin cerebellar ataxia
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Anti neurochondrin cerebellar ataxia. This is an autoimmune non-paraneoplastic cerebellar ataxia. Fully referenced neurology checklist.
Pathogenesis
- This is an autoimmune non-paraneoplastic cerebellar ataxia
- It is caused by anti-neurochondrin (NCDN) antibodies
- These belong to the Medussa head antibody spectrum
Clinical features
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Magnetic resonance imaging (MRI): features
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Cerebrospinal fluid (CSF) analysis: features
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Treatment
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References
- Shelly S, Kryzer TJ, Komorowski L, et al. Neurochondrin neurological autoimmunity. Neurol Neuroimmunol Neuroinflamm 2019; pii: e612.
- Weihua Z, Haitao R, Fang F, Xunzhe Y, Jing W, Hongzhi G. Neurochondrin antibody serum positivity in three cases of autoimmune cerebellar ataxia. Cerebellum 2019; 18:1137-1142.
- Miske R, Gross CC, Scharf M, et al. Neurochondrin is a neuronal target antigen in autoimmune cerebellar degeneration. Neurol Neuroimmunol Neuroinflamm 2016; 4:e307.
