Anti Ma2 antibody paraneoplastic syndrome: causes and triggers

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Anti Ma2 antibody paraneoplastic syndrome: causes and triggers. Testicular germ cell tumours, Testicular carcinoma. Fully referenced neurology checklist.

Causative tumours

  • Testicular germ cell tumours
  • Testicular carcinoma
  • Hodgkin’s lymphoma
  • Non-Hodgkin’s lymphoma
  • Small cell lung cancer
  • Lung adenocarcinoma
  • Breast cancer
  • Cervical cancer
  • Mediastinal seminoma
  • Prostatic adenocarcinoma

Drug triggers

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References

  1. Murphy SM, Khan U, Alifrangis C, et al. Anti Ma2-associated myeloradiculopathy: expanding the phenotype of anti-Ma2 associated paraneoplastic syndromes. JNNP 2012; 83:232-233.
  2. Hoffman LA, Jarius S, Pellkofer HL, et al. Anti-Ma and anti-Tr associated paraneoplastic neurological syndromes: 22 newly diagnosed patients and review of previous cases. JNNP 2008; 79:767-773.
  3. Ortega Suero G, Sola-Valls N, Escudero D, Saiz A, Graus F. Anti-Ma and anti-Ma2-associated paraneoplastic neurological syndromes. Neurologia (Engl Ed) 2018; 33:18-27. 
  4. Suwijn SR, Klieverik LP, Odekerken VJJ. Anti-Ma2-associated encephalitis in a patient with testis carcinoma. Neurology 2016; 86:1461.
  5. Honnorat J, Antoine JC. Paraneoplastic neurological syndromes. Orphant J Rare Dis 2007; 2:22.
  6. And 12 more. Subscribe to see the full list

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