Anti-glycine receptor syndrome: management

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Anti-glycine receptor syndrome: management. Protein: this is raised, White cell counts: these are high. Fully referenced neurology checklist.

Cerebrospinal fluid (CSF) analysis

  • Protein: this is raised
  • White cell counts: these are high
  • Oligoclonal bands (OCBs): these are present

Magnetic resonance imaging (MRI) brain

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Acute treatment

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Long-term immunosuppressive treatment

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Other treatments

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Acronym

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References

  1. Hinson SR, Lopez-Chiriboga AS, Bower JH, et al. Glycine receptor modulating antibody predicting treatable stiff-person spectrum disorders. Neurol Neuroimmunol Neuroinflamm 2018; 5:e438.
  2. McKeon A, Martinez-Hernandez E, Lancaster E, et al. Glycine receptor autoimmune spectrum with stiff-man syndrome phenotype. JAMA Neurol 2013; 70:44-50. 
  3. Iizuka T, Tominaga N, Kaneko J. Clinical spectrum of anti-glycine receptor antibody-associated disease. Rinsho Shinkeigaku 2013; 53:1063-1066.

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