Anti-GAD cerebellar ataxia
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Anti-GAD cerebellar ataxia. This is caused by anti-GAD65 antibodies. The antibodies may be paraneoplastic. Fully referenced neurology checklist.
Pathology
- This is caused by anti-GAD65 antibodies
- The antibodies may be paraneoplastic
Demographic features
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Prodromal features
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Clinical features
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Associated autoimmune diseases
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Cerebrospinal fluid (CSF) analysis
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Magnetic resonance imaging (MRI) brain
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Acute treatment
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Maintenance treatment
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References
- Ariño H, Gresa-Arribas N, Blanco Y, et al. Cerebellar ataxia and glutamic acid decarboxylase antibodies: immunologic profile and long-term effect of immunotherapy. JAMA Neurol 2014; 71:1009-1016.
- Kuchling J, Shababi-Klein J, Nümann A, Gerischer LM, Harms L, Prüss H. GAD antibody-associated late-onset cerebellar ataxia in two female siblings. Case Rep Neurol 2014; 6:264-270.
- Bayreuther C, Hieronimus S, Ferrari P, Thomas P, Lebrun C. Auto-immune cerebellar ataxia with anti-GAD antibodies accompanied by de novo late-onset type 1 diabetes mellitus. Diabetes Metab 2008; 34:386-388.
- Saiz A, Arpa J, Sagasta A, et al. Autoantibodies to glutamic acid decarboxylase in three patients with cerebellar ataxia, late-onset insulin-dependent diabetes mellitus, and polyendocrine autoimmunity. Neurology 1997; 49:1026-1030.
