Amyloid myopathy: clinical features
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Amyloid myopathy: clinical features. Limb weakness, Axial weakness, Dysphagia, Dropped head syndrome, Hoarseness. Fully referenced neurology checklist.
Muscle symptoms
- Limb weakness
- Axial weakness
- Dysphagia
- Dropped head syndrome
- Hoarseness
- Myalgia
- Jaw claudication
- Fatigue
- Rhabdomyolysis
- Asymptomatic hyperCKaemia
Muscle signs
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Systemic features
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Associated features of amyloidosis
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Features indicative of isolated amyloid myopathy
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Differential diagnosis
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References
- Liewluck T, Milone M. Characterization of isolated amyloid myopathy. Eur J Neurol 2017; 24:1437-1445.
- Muchtar E, Derudas D, Mauermann M, et al. Systemic immunoglobulin light chain amyloidosis-associated myopathy: presentation, diagnostic pitfalls, and outcome. Mayo Clin Proc 2016; 91:1354-1361.
- Jennekens FG, Wokke JH. Proximal weakness of the extremities as main feature of amyloid myopathy. JNNP 1987; 50:1353-1358.
- Vaish AK, Mehrotra S, Kushwaha MR. Proximal muscle weakness due to amyloid deposition. JNNP 1998; 64:409-410.
- Malek N, O'Donovan DG, Manji H. AL amyloidosis presenting with limb girdle myopathy. Pract Neurol 2018; 18:497-500.
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