Agyrophilic grain disease (AGD): pathology
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Agyrophilic grain disease (AGD): pathology. This is a four-repeat tauopathy of older people. Fully referenced neurology checklist.
Pathology
- This is a four-repeat tauopathy of older people
- It is sporadic: there are no familial cases
- it predominantly affects the limbic structures
Pathological features
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Pathological stages
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Magnetic resonance imaging (MRI) brain
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References
- Yokota O, Miki T, Ikeda C, et al. Neuropathological comorbidity associated with argyrophilic grain disease. Neuropathology 2018; 38:82-97.
- Grinberg LT, Heinsen H. Argyrophilic grain disease: an update about a frequent cause of dementia. Dement Neuropsychol 2009; 3:2-7.
- Togo T, Sahara N, Yen SH, et al. Argyrophilic grain disease is a sporadic 4-repeat tauopathy. J Neuropathol Exp Neurol 2002; 61:547-556.
- Ikeda C, Yokota O, Miki T, et al. Astrocytic tau pathologies in argyrophilic grain disease and related four-repeat tauopathies. Acta Med Okayama 2018; 72:211-221.
- Rodriguez RD, Grinberg LT. Argyrophilic grain disease: an underestimated tauopathy. Dement Neuropsychol 2015; 9:2-8.
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