Agyrophilic grain disease (AGD): clinical features
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Agyrophilic grain disease (AGD): clinical features. This is a four-repeat tauopathy of older people. Fully referenced neurology checklist.
Demographic features
- This is a four-repeat tauopathy of older people
- The prevalence is 9.3% in people >65 years
- It may present in people as young as 49 years
Risk factors
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Neurological features: dementia
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Neurological features: others
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Psychiatric features
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Systemic features
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Associated disorders
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Possible associated disorders
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References
- Yokota O, Miki T, Ikeda C, et al. Neuropathological comorbidity associated with argyrophilic grain disease. Neuropathology 2018; 38:82-97.
- Grinberg LT, Heinsen H. Argyrophilic grain disease: an update about a frequent cause of dementia. Dement Neuropsychol 2009; 3:2-7.
- Rodriguez RD, Grinberg LT. Argyrophilic grain disease: an underestimated tauopathy. Dement Neuropsychol 2015; 9:2-8.
- Rodriguez RD, Suemoto CK, Molina M, et al. Argyrophilic grain disease: demographics, clinical, and neuropathological features from a large autopsy study. J Neuropathol Exp Neurol 2016; 75:628-635.
- Jicha GA, Petersen RC, Knopman DS, et al. Argyrophilic grain disease in demented subjects presenting initially with amnestic mild cognitive impairment. J Neuropathol Exp Neurol 2006; 65:602-609.
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