Adverse effects of epilepsy on pregnancy

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Adverse effects of epilepsy on pregnancy. Polycystic ovary syndrome, Hypothalamic amenorrhea. Fully referenced neurology checklist.

Adverse effects on reproductive ability

  • Polycystic ovary syndrome
  • Hypothalamic amenorrhea
  • Premature ovarian failure
  • Anovulatory cycles from functional hyperprolactinemia
  • Reduced libido

Adverse effects on the foetus

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Effects on delivery

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References

  1. Harden C, Hopp J, Ting TY, et al. Management issues for women with epilepsy-focus on pregnancy (an evidence-based review): I. Obstetrical complications and change in seizure frequency. Epilepsia 2009; 50:1229-1236.
  2. Nucera B, Brigo F, Trinka E, Kalss G. Treatment and care of women with epilepsy before, during, and after pregnancy: a practical guide. Ther Adv Neurol Disord 2022; 15:17562864221101687. 
  3. Sawle GV, Ramsay MM. The neurology of pregnancy. JNNP 1998; 64:711-725.
  4. Tomson T, Battino D, Bonizzoni E, et al; EURAP Study Group. Antiepileptic drugs and intrauterine death: A prospective observational study from EURAP. Neurology 2015; 85:580-588.

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