White matter lesions (WML): disease patterns
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
White matter lesions (WML): disease patterns. White matter lesions here are initially occipital. Fully referenced neurology checklist.
Adrenoleukodystrophy (ALD)
- White matter lesions here are initially occipital
- They affect the splenium of the corpus callosum and the posterior limb of the internal capsule
- There is peripheral contrast enhancement
- Spinal cord atrophy may be present
Adult onset Alexander disease
Locked: subscribe to see this section.
CADASIL
Locked: subscribe to see this section.
Cerebrotendinous xanthomatosis (CTX)
Locked: subscribe to see this section.
Krabbe disease
Locked: subscribe to see this section.
Metachromatic leukodystrophy (MLD)
Locked: subscribe to see this section.
Mitochondrial disorders
Locked: subscribe to see this section.
Vanishing white matter disease (VWM)
Locked: subscribe to see this section.
Acronym
Locked: subscribe to see this section.
References
- Ahmed RM, Murphy E, Davagnanam I, et al. A practical approach to diagnosing adult onset leukodystrophies. JNNP 2014; 85:770-781.
- Bhidayasiri R, Waters MF, Giza CC. Neurological Differential Diagnosis. A Prioritized Approach. Blackwell Publishing Massachusetts 2005 p 423-425.
- Leite CC, Lucato LT, Santos GT, Kok F, Brandão AR, Castillo M. Imaging of adult leukodystrophies. Arq Neuropsiquiatr 2014; 72:625-632.
