Tyrosine kinase inhibitors (TKI): imatinib

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Tyrosine kinase inhibitors (TKI): imatinib. KIT-positive gastrointestinal stromal tumours (GIST). Fully referenced neurology checklist.

Indications

  • Philadelphia-chromosome positive chronic myeloid leukaemia (CML)
  • KIT-positive gastrointestinal stromal tumours (GIST)

Neurological complications

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Ophthalmic complications

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Dermatological complications

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Gastrointestinal complications

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Hepatic complications

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Cardiac complications

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Respiratory complications

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Other complications

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Treatment of neurological complications

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Acronym

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References

  1. Rotstein DL, Sawicka K, Bharatha A, Montalban X, Lipton JH. CNS demyelination after initiating the tyrosine kinase inhibitor imatinib: A report of two cases. Mult Scler 2019 (Epub ahead of print).
  2. Feki J, Marrekchi G, Boudawara T, et al. Subdural hematoma during therapy of gastro-intestinal stromal tumor (GIST) with Imatinib mesylate. Gulf J Oncolog 2015; 1:92-95.
  3. Gulati AP, Saif MW. Retinal neovascularization and hemorrhage associated with the use of imatinib (Gleevec(®)) in a patient being treated for gastrointestinal stromal tumor (GIST). Anticancer Res 2012; 32:1375-1377.
  4. Rotstein DL, Sawicka K, Bharatha A, Montalban X, Lipton JH. CNS demyelination after initiating the tyrosine kinase inhibitor imatinib: A report of two cases. Mult Scler 2020; 26:1121-1124.
  5. Theodotou CB, Shah AH, Ivan ME, Komotar RJ. Subdural hematoma in a patient taking imatinib for GIST: a case report and discussion of risk with other chemotherapeutics. Anticancer Drugs 2016; 27:259-263.
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