Triptans: drug interactions
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Triptans: drug interactions. SSRIs: but risk of serious serotonin syndrome is low, Tricyclics, Nefazodone, Trazodone. Fully referenced neurology checklist.
Interactions with anti-depressants
- SSRIs: but risk of serious serotonin syndrome is low
- Tricyclics
- Nefazodone
- Trazodone
- Venlafaxine
- Bupropion
- Monoamine oxidase inhibitors (MAOI): these increase the bioavailability of some triptans
Other interactions
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References
- Demaagd G. The pharmacological management of migraine, part 1: overview and abortive therapy. P T 2008; 33:404-416.
- Tepper SJ. Safety and rational use of the triptans. Med Clin North Am 2001; 85:959-970.
- Millson DS, Tepper SJ, Rapoport AM. Migraine pharmacotherapy with oral triptans: a rational approach to clinical management. Expert Opin Pharmacother 2000; 1:391-404.
- Gillman PK. Triptans, serotonin agonists, and serotonin syndrome (serotonin toxicity): a review. Headache 2010; 50:264-272.
