Thyrotoxic periodic paralysis: clinical features
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Thyrotoxic periodic paralysis: clinical features. Kir2.6 gene mutations may occur. Fully referenced neurology checklist.
Genetics and pathology
- Kir2.6 gene mutations may occur
- It is associated with hyperthyroidism
- Features of thyrotoxicosis may be subtle
Demographic features
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Prodromal features
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Features of weakness
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Drug triggers
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Other triggers
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Differential diagnosis
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References
- Finsterer J. Primary periodic paralyses. Acta Neurol Scand 2008; 117:145-158.
- Kung AW. Clinical review: Thyrotoxic periodic paralysis: a diagnostic challenge. J Clin Endocrinol Metab 2006; 91:2490-2495.
- Lulsegged A, Wlodek C, Rossi M. Thyrotoxic periodic paralysis: case reports and an up-to-date review of the literature. Case Rep Endocrinol 2011; 2011:867475.
- Scheive M, Patel N, Saeed Z. High-dose intravenous hydrocortisone for the treatment of hyperthyroidism: a rare precipitant of thyrotoxicosis periodic paralysis. Endocrinol Diabetes Metab Case Rep 2023; 2023:22-0358.
- Batra J, Ankireddypalli A, Kanugula AK, Gorle S, Kaur J. Thyrotoxic periodic paralysis with severe hypokalemia precipitated by acute alcohol intoxication in a patient with Graves' disease. Cureus 2023; 15:e35548.
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