Superficial siderosis (SS): investigations

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Superficial siderosis (SS): investigations. Surface of cerebellum, brain stem, and spinal cord. Fully referenced neurology checklist.

Magnetic resonance imaging (MRI): location of diffuse hypointensities

  • Surface of cerebellum, brain stem, and spinal cord
  • Along cerebellar folia and vermis
  • Interhemispheric
  • Sylvian fissure
  • Along vestibulochochlear nerve

Magnetic resonance imaging (MRI): other features

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Cerebrospinal fluid (CSF) analysis

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References

  1. Messori A, Bella PD, Herber N, Logullo F, Ruggiero M, Salvolini U. The importance of suspecting superficial siderosis of the central nervous system in clinical practice. JNNP 2004; 75:188-190.
  2. Kumar N. Superficial siderosis: associations and therapeutic implications. Arch Neurol 2007; 64:491-496.
  3. Kumar N, Bledsoe JM, Davis DH. Intracranial fluid filled collection and superficial siderosis. JNNP 2007; 78:652-653.
  4. Charidimou A, Boulouis G, Xiong L, et al. Cortical superficial siderosis and first-ever cerebral hemorrhage in cerebral amyloid angiopathy. Neurology 2017; 88:1607-1614.
  5. Moulin S, Casolla B, Kuchcinski G, et al. Cortical superficial siderosis: a prospective observational cohort study. Neurology 2018; 91:e132-e138.
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