Sporadic fatal insomnia (SFI): pathology
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Sporadic fatal insomnia (SFI): pathology. There is thalamic degeneration and atrophy. Fully referenced neurology checklist.
Gross pathology
- There is thalamic degeneration and atrophy
- There is neuronal loss and astrogliosis
- There is spongiform degeneration in the thalamus and cortex
Prion protein pathology
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Synonym
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References
- Moody KM, Schonberger LB, Maddox RA, Zou WQ, Cracco L, Cali I. Sporadic fatal insomnia in a young woman: a diagnostic challenge: case report. BMC Neurol 2011; 11:136.
- Priano L, Giaccone G, Mangieri M, et al. An atypical case of sporadic fatal insomnia. JNNP 2009; 80:924-927.
- Piao YS, Kakita A, Watanabe H, Kitamoto T, Takahashi H. Sporadic fatal insomnia with spongiform degeneration in the thalamus and widespread PrPSc deposits in the brain. Neuropathology 2005; 25:144-149.
