Skin biopsy
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Skin biopsy. Skin biopsy mainly assesses the intra-epithelial nerve fibers (IENF). Fully referenced neurology checklist.
Background
- Skin biopsy mainly assesses the intra-epithelial nerve fibers (IENF)
- It is more sensitive and flexible, and less invasive, than nerve biopsy
- It can also be performed using a skin blister
Indications
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Intraepidermal nerve fibers (IENFs)
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Neurological causes of reduced IENFD
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Non-neurological causes of reduced IENFD
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Conditions with normal IENFD
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Skin biopsy markers of uncertain significance
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Causes of absent innervation of sweat glands
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Miscellaneous findings on skin biopsy
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References
- Lauria G, Faber CG, Cornblath DR. Skin biopsy and small fibre neuropathies: facts and thoughts 30 years later. JNNP 2022; 93:915-918.
- Nolano M, Tozza S, Caporaso G, Provitera V. Contribution of skin biopsy in peripheral neuropathies. Brain Sci 2020; 10:989.
- Sommer C, Lauria G. Skin biopsy in the management of peripheral neuropathy. Lancet Neurol 2007; 6:632-642.
- Raicher I, Ravagnani LHC, Correa SG, Dobo C, Mangueira CLP, Macarenco RSES. Investigation of nerve fibers in the skin by biopsy: technical aspects, indications, and contribution to diagnosis of small-fiber neuropathy. Einstein (Sao Paulo) 2022; 20:eMD8044.
- Lauria G, Devigili G. Skin biopsy as a diagnostic tool in peripheral neuropathy. Nat Clin Pract Neurol 2007; 3:546-557.
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