Scrub typhus: management

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Scrub typhus: management. IgM enzyme-linked immunosorbent assay (ELISA), Immunofluorescence assay (IFA). Fully referenced neurology checklist.

Immunological investigations

  • IgM enzyme-linked immunosorbent assay (ELISA)
  • Immunofluorescence assay (IFA)
  • Immunochromatographic test (ICT)
  • The Weil–Felix test
  • Loop-mediated isothermal amplification assay (LAMP)
  • Polymerase chain reaction (PCR)
  • Metagenomic next-generation sequencing (mNGS)

Laboratory features

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Cerebrospinal fluid (CSF) analysis

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Treatment

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References

  1. Basu S, Chakravarty A. Neurological manifestations of scrub typhus. Curr Neurol Neurosci Rep 2022; 22:491-498.
  2. Alam AM, Gillespie CS, Goodall J, et al. Neurological manifestations of scrub typhus infection: A systematic review and meta-analysis of clinical features and case fatality. PLoS Negl Trop Dis 2022; 16:e0010952.
  3. Garg D, Manesh A. Neurological facets of scrub typhus: a comprehensive narrative review. Ann Indian Acad Neurol 2021; 24:849-864.

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