Prolonged disorders of consciousness (PDOC): treatment
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Prolonged disorders of consciousness (PDOC): treatment. This is indicated for adults with traumatic PDOC. Fully referenced neurology checklist.
Amantadine
- This is indicated for adults with traumatic PDOC
- The dose 100-200 mg bid
- It is used between 4-16 weeks after the injury
- It may hasten functional recovery
- It may reduce early disability
Investigational treatments
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References
- Giacino JT, Katz DI, Schiff ND, et al. Practice guideline update recommendations summary: Disorders of consciousness: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology; the American Congress of Rehabilitation Medicine; and the National Institute on Disability, Independent Living, and Rehabilitation Research. Neurology 2018; 91:450-460.
- Thibaut A, Schiff N, Giacino J, Laureys S, Gosseries O. Therapeutic interventions in patients with prolonged disorders of consciousness. Lancet Neurol 2019; 18:600-614.
