Progressive myoclonic epilepsy (PME): clinical features
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Progressive myoclonic epilepsy (PME): clinical features. These manifest as cortical reflex myoclonus. Fully referenced neurology checklist.
Myoclonic seizures
- These manifest as cortical reflex myoclonus
- They are stimulus sensitive: to light, sound, and touch
- They are fragmentary and multifocal
- They especially occur in the face and distal limbs
- They may present as massive bilateral proximal myoclonus
Other seizure types: in Lafora body disease
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Cerebellar features
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Ophthalmic features
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Other neurological features
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Other features
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References
- Cameron JM, Ellis CA, Berkovic SF, et al. ILAE genetics literacy series: progressive myoclonus epilepsies. Epileptic Disord 2023 (Online ahead of print).
- Franceschetti S, Michelucci R, Canafoglia L, et al. Progressive myoclonic epilepsies: definitive and still undetermined causes. Neurology 2014; 82:405-411.
