Primary lateral sclerosis (PLS): investigations
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Primary lateral sclerosis (PLS): investigations. Electromyogram (EMG) is abnormal. Fully referenced neurology checklist.
Neurophysiology
- Electromyogram (EMG) is abnormal
- Nerve conduction studies (NCS): this shows minor sensory features
Magnetic resonance imaging (MRI): features
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Magnetic resonance spectroscopy (MRS): features
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Genetic tests
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Emerging investigations
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References
- Pringle CE, Hudson AJ, Munoz DG, et al. Primary lateral sclerosis: clinical features, neuropathology and diagnostic criteria. Brain 1992; 115:495-520.
- Turner MR, Barohn RJ, Corcia P, et al. Primary lateral sclerosis: consensus diagnostic criteria. JNNP 2020; 91:373-377.
- Zhai P, Pagan F, Statland J, Butman JA, Floeter MK. Primary lateral sclerosis: a heterogenous disorder composed of different subtypes. Neurology 2003; 60:1258-1265.
