Postural tachycardia syndrome (POTS): causes

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Postural tachycardia syndrome (POTS): causes. Neuropathic, Hyperadrenergic, Impaired cerebral autoregulation. Fully referenced neurology checklist.

Primary causes

  • Neuropathic
  • Hyperadrenergic 
  • Hypovolemic: this is due to reduced blood and red cell volume
  • Impaired cerebral autoregulation
  • Genetic

Secondary causes

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Medical triggers

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Drug triggers

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References

  1. Carew S, Connor MO, Cooke J, et al. A review of postural orthostatic tachycardia syndrome. Europace 2009; 11:18-25.
  2. Grubb BP. Neurocardiogenic syncope and related disorders of orthostatic intolerance. Circulation 2005; 111:2997-3006.
  3. Agarwal AK, Garg R, Ritch A, Sarkar P. Postural orthostatic tachycardia syndrome. Postgrad Med J 2007; 83:478-480.
  4. Kanjwal K, Karabin B, Kanjwal Y, Grubb BP. Postural orthostatic tachycardia syndrome following Lyme disease. Cardiol J 2011; 18:63-66.
  5. Johansson M, Ståhlberg M, Runold M, et al. Long-haul post-COVID-19 symptoms presenting as a variant of postural orthostatic tachycardia syndrome: the Swedish experience. JACC Case Rep 2021; 3:573-580.
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