Post-traumatic hypopituitarism (PTHP)
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Post-traumatic hypopituitarism (PTHP). This is a constellation of hypopituitary symptoms that develop after TBI. Fully referenced neurology checklist.
Pathology
- This is a constellation of hypopituitary symptoms that develop after TBI
- It is present in about a quarter of cases of TBI
- It may present years after TBI
Risk factors
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Clinical features
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Potential mechanisms
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Predictive features
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Magnetic resonance imaging (MRI)
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Management
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Prognosis
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References
- Leeder S. Traumatic brain injury and hypopituitarism. ACNR 2019; 18:6-9.
- Sav A, Rotondo F, Syro LV, Serna CA, Kovacs K. Pituitary pathology in traumatic brain injury: a review. Pituitary 2019; 22:201-211.
- Kgosidialwa O, Agha A. Hypopituitarism post traumatic brain injury (TBI): review. Ir J Med Sci 2019; 188:1201-1206.
- Kałas M, Miksiewicz M, Kowalke A, Siemiński M. Post-traumatic hypopituitarism: a neglected consequence of traumatic brain injury. Neuroendocrinology 2023; 113:579-588.
- Caputo M, Mele C, Prodam F, Marzullo P, Aimaretti G. Clinical picture and the treatment of TBI-induced hypopituitarism. Pituitary 2019; 22:261-269.
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