Post-hypoxic myoclonus (PHM): management

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Post-hypoxic myoclonus (PHM): management. Spike or polyspike-wave discharges, Diffuse or focal slowing. Fully referenced neurology checklist.

Neurophysiology: cortical features

  • Spike or polyspike-wave discharges
  • Diffuse or focal slowing
  • Jerk-locking on EEG-EMG polygraphy
  • Giant somatosensory evoked potentials (SSEPs)

Neurophysiology: subcortical features

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Positron emission tomography (PET) scan

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Single photon emission tomography (SPECT) scan

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Anti-epileptic drug (AED) treatment

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Other treatments

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Synonym

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References

  1. Freund B, Kaplan PW. Post-hypoxic myoclonus: differentiating benign and malignant etiologies in diagnosis and prognosis. Clin Neurophysiol Pract 2017; 2:98-102.
  2. Ramdhani RA, Frucht SJ, Kopell BH. Improvement of post-hypoxic myoclonus with bilateral pallidal deep brain stimulation: a case report and review of the literature. Tremor Other Hyperkinet Mov (N Y) 2017; 7:461.
  3. Cho AR, Kwon JY, Kim JY, Kim ES, Kim HY. Acute onset Lance-Adams syndrome following brief exposure to severe hypoxia without cardiac arrest-a case report. Korean J Anesthesiol 2013; 65:341-344.
  4. Freund B, Kaplan PW. Myoclonus after cardiac arrest: where do we go from here? Epilepsy Curr 2017; 17:265-272.
  5. Bouwes A, van Poppelen D, Koelman JH, et al. Acute posthypoxic myoclonus after cardiopulmonary resuscitation. BMC Neurol 2012; 12:63. 
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