Plasma exchange (PE)

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Plasma exchange (PE). Severe Guillain Barre syndrome (GBS). Fully referenced neurology checklist.

Level A evidenced indications

  • Severe Guillain Barre syndrome (GBS)
  • Severe chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)

Level B evidenced indications

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Lower evidenced indications

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Pre-procedure investigations

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Pre-procedure precautions

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Complications of procedure

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Complications of vascular access

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Acronym

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References

  1. Cortese I, Chaudhry V, So YT, et al. Evidence-based guideline update: plasmapheresis in neurologic disorders. Report of the Therapeutics and Technology Assessment Subcommittee of the American Association of Neurology. Neurology 2011; 76:294-300.
  2. Osman C, Jennings R, El-Ghariani K, Pinto A. Plasma exchange in neurological disease. Pract Neurol 2020; 20:92-99.
  3. Sinanović O, Zukić S, Burina A, et al. Plasmapheresis in neurological disorders: six years experience from University Clinical center Tuzla. F1000Res 2017; 6:1234. 
  4. Strasser E. Principles of therapeutic apheresis in neurological disease. Transfus Med Hemother 2023; 50:88-97.
  5. Shemin D, Briggs D, Greenan M. Complications of therapeutic plasma exchange: a prospective study of 1,727 procedures. J Clin Apher 2007; 22:270-276.
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