Phenytoin: clinical use
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Phenytoin: clinical use. Phenytoin inhibits voltage gated sodium channels (VGSC). Fully referenced neurology checklist.
Mode of action
- Phenytoin inhibits voltage gated sodium channels (VGSC)
- It promotes sodium efflux from neurones
- Phosphenytoin is a phenytoin pro-drug
Indications
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Dosing
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Long-term monitoring (2-5 yearly)
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References
- Zaccara G, Cincotta A, Borgheresi F, Balestrieri F. Adverse motor effects induced by antiepileptic drugs. Epileptic Disord 2004; 6:153-168.
- Asconapé JJ. Some common issues in the use of antiepileptic drugs. Semin Neurol 2002; 22:27-39.
- Mantegazza M, Curia G, Biagini G, Ragsdale DS, Avoli M. Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders. Lancet Neurol 2010; 9:413-424.
- Goldenberg MM. Overview of drugs used for epilepsy and seizures: etiology, diagnosis, and treatment. P T 2010; 35:392-415.
- Popławska M, Borowicz KK, Czuczwar SJ. The safety and efficacy of fosphenytoin for the treatment of status epilepticus. Expert Rev Neurother 2015; 15:983-992.
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