Paroxysmal hypothermia: clinical features

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Paroxysmal hypothermia: clinical features. Hypothermia, Bradycardia, Impaired consciousness. Fully referenced neurology checklist.

Major recurrent features

  • Hypothermia
  • Bradycardia
  • Impaired consciousness

Diagnostic criteria

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Constitutional features

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Neurological features

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Cardiorespiratory features

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Gastrointestinal features

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Psychiatric features

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Haematological features

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Other features

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References

  1. Devic P, Peter-Derex L, Richard-Mornas A, et al. Late-onset post-lesional paroxysmal hypothermia: a case series and literature review. J Neurol 2020; 267:3301-3309.
  2. Erlich-Malona N, Bartolini L, D'Abreu A, Roth J. Paroxysmal hypothermia with prominent parkinsonian features after suprachiasmatic tumor resection. Neurohospitalist 2022; 12:285-289. 
  3. Ren L, Gang X, Yang S, Sun M, Wang G. A new perspective of hypothalamic disease: Shapiro's syndrome. Front Neurol 2022; 13:911332.
  4. Topcu Y, Bayram E, Karaoglu P, Yis U, Kurul SH. The combination of thermal dysregulation and agenesis of corpus callosum: Shapiro's or/and reverse Shapiro's syndrome. Ann Indian Acad Neurol 2013; 16:716-719.
  5. Hirayama K, Hoshino Y, Kumashiro H, Yamamoto T. Reverse Shapiro's syndrome. A case of agenesis of corpus callosum associated with periodic hyperthermia. Arch Neurol 1994; 51:494-496.
  6. And 4 more. Subscribe to see the full list

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