Parkinson's disease (PD): differential diagnosis
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Parkinson's disease (PD): differential diagnosis. Dementia with Lewy bodies (DLB). Fully referenced neurology checklist.
Parkinson’s plus syndromes
- Multiple system trophy (MSA): the following are more impaired in MSA
- Dementia with Lewy bodies (DLB)
- Progressive supranuclear palsy (PSP)
- Corticobasal degeneration (CBD)
Other neurodegenerative disorders
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Developmental disorders
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Chromosomal disorders
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Brain tumours
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Brain cysts
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Other brain structural disorders
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Toxin-induced Parkinsonism
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Drug-induced Parkinsonism
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Other differentials
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Red flags against PD diagnosis
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References
- Massano J, Bhatia K. Clinical approach to Parkinson's disease: features, diagnosis, and principles of management. Cold Spring Harb Perspect Med 2012; 2:a008870.
- Gigante AF, Berardelli A, Defazio G. Rest tremor in idiopathic adult-onset dystonia. Eur J Neurol 2016; 23:935-939.
- Shin HW, Hong SW, Youn YC. Clinical aspects of the differential diagnosis of Parkinson's disease and Parkinsonism. J Clin Neurol 2022; 18:259-270.
- von Scheibler ENMM, van Eeghen AM, de Koning TJ, et al. Parkinsonism in genetic neurodevelopmental disorders: a systematic review. Mov Disord Clin Pract 2022; 10:17-31.
- Sista SR, Dronacharya L. Manganese supplementation as a cause of parkinsonism and T1-hyperintensities on basal ganglia. Neurol Clin Pract 2021; 11:e361-e362.
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