Paraproteinaemic neuropathy: management
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Paraproteinaemic neuropathy: management. Routine bloods, Immunoglobulin concentrations: IgG, IgA, IgM. Fully referenced neurology checklist.
General investigations
- Routine bloods
- Immunoglobulin concentrations: IgG, IgA, IgM
- Serum protein immunofixation (IF)
- Serum plasma electrophoresis (SPEP)
- Bence Jones protein
- Cryoglobulins
- C reactive protein (CRP)
- Lactic dehydrogenase (LDH)
- Bone marrow aspiration
Conditional general investigations
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Neurological investigations
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Radiological investigations
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Treatment of paraproteinaemic neuropathy
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Acronym
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References
- Dalakas MC. Pathogenesis and treatment of anti-MAG neuropathy. Curr Treat Options Neurology 2010; 12:71-83.
- Karam C, Moshe-Lilie O, Chahin N, Ragole T, Medvedova E, Silbermann R. Diagnosis of paraproteinemic neuropathy: room for improvement. J Neurol Sci 2020; 415:116902.
- Haden RDM, Nobile-Orizo E, Sommer C, et al. European Federation of Neurological Societies/Peripheral Nerve Society guideline on management of paraproteinaemic demyelinating neuropathies. Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society. Eur J Neurol 2006, 13:809–818.
