Paraneoplastic encephalitis (PE): management
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Paraneoplastic encephalitis (PE): management. Paraneoplastic antibody screening, Full-body CT. Fully referenced neurology checklist.
Investigations: non-invasive
- Paraneoplastic antibody screening
- Full-body CT
- Positron emission tomography (PET)
- Magnetic resonance imaging (MRI) brain
- Electroencephalogram (EEG)
Investigations: surgical exploration
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Symptomatic treatments
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First line immunotherapy
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Second line immunotherapy
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Other treatments
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References
- Vaišvilas M, Ciano-Petersen NL, Macarena Villagrán-García MD, Muñiz-Castrillo S, Vogrig A, Honnorat J. Paraneoplastic encephalitis: clinically based approach on diagnosis and management. Postgrad Med J 2023 (Online ahead of print).
- Honnorat J, Antoine JC. Paraneoplastic neurological syndromes. Orphant J Rare Dis 2007; 2:22.
- Voltz RD, Posner JB, Dalmau J, Graus F. Paraneoplastic encephalomyelitis: an update of the effects of the anti-Hu immune response on the nervous system and tumour. JNNP 1997; 63:133-136.
- Grisold W, Giometto B, Vitaliani R, Oberndorfer S. Current approaches to the treatment of paraneoplastic encephalitis. Ther Adv Neurol Disord 2011; 4:237-248.
- Batson OA, Fantle DM, Stewart JA. Paraneoplastic encephalomyelitis. Dramatic response to chemotherapy alone. Cancer 1992; 69:1291-1293.
