Opsoclonus myoclonus syndrome (OMS): causes
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Opsoclonus myoclonus syndrome (OMS): causes. Anti-glutamate receptor δ2 antibodies (anti GluD2). Fully referenced neurology checklist.
Primary neurological causes
- Idiopathic (I-OMS): this has a younger onset and better outcomes
- Anti-glutamate receptor δ2 antibodies (anti GluD2)
- Anti-dendritic surface receptor antibodies
- Hydrocephalus
- Lafora body disease
- Multiple sclerosis (MS)
- Friedreich's ataxia (FA)
- Thalamic haemorrhage
- Pontine haemorrhage
Paraneoplastic (P-OMS)
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Viral causes
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Bacterial causes
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Other causes
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References
- Sahu JK, Prasad K. The opsoclonus myoclonus syndrome. Pract Neurol 2011; 11:160-166.
- Pranzatelli MR. The neurobiology of the opsoclonus-myoclonus syndrome. Clin Neuropharmacol 1992; 15:186-228.
- Armangué T, Sabater L, Torres-Vega E, et al. Clinical and immunological features of opsoclonus-myoclonus syndrome in the era of neuronal cell surface antibodies. JAMA Neurol 2016; 73:417-424.
- Berridge G, Menassa DA, Moloney T, et al. Glutamate receptor δ2 serum antibodies in pediatric opsoclonus myoclonus ataxia syndrome. Neurology 2018; 91:e714-e723.
- Panzer JA, Anand R, Dalmau J, Lynch DR. Antibodies to dendritic neuronal surface antigens in opsoclonus myoclonus ataxia syndrome. J Neuroimmunol 2015; 286:86-92.
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