Normal pressure hydrocephalus (NPH): other treatments

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Normal pressure hydrocephalus (NPH): other treatments. This is reportedly safe and effective for NPH. Fully referenced neurology checklist.

Endoscopic third ventriculostomy

  • This is reportedly safe and effective for NPH
  • A younger age predicts good outcomes
  • Incontinence and cognitive impairment predict poorer outcomes

Acetazolamide

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Acronyms

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References

  1. Komlakh K, Oveisi H, Aghamiri SH. Evaluation of treatment response results in patients with normal-pressure hydrocephalus undergoing surgery. J Family Med Prim Care 2023; 12:101-105.
  2. Komlakh K, Oveisi H, Hossein Aghamiri S. Endoscopic third ventricolustomy as treatment option for normal pressure hydrocephalus. Eur J Transl Myol 2022; 32:10618.
  3. Koutsouras GW, Steinmetz E, Tichenor M, Schmidt B, Mohan YS, Krishnamurthy S. Endoscopic third ventriculostomy and cortical biopsy in patients with normal pressure hydrocephalus. Cureus 2022; 14:e31523. 
  4. Alperin N, Oliu CJ, Bagci AM, et al. Low-dose acetazolamide reverses periventricular white matter hyperintensities in iNPH. Neurology 2014; 82:1347-1351.
  5. Virhammar J, Fasth O, Ekblom M, et al. Safety, tolerability, and efficacy of acetazolamide in idiopathic normal pressure hydrocephalus (DRAIN) in Sweden: a randomised, double-blind, placebo-controlled, phase 2 trial. Lancet Neurol 2026; 25:550-559.

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