Non-arteritic anterior ischaemic optic neuropathy (NAION): clinical features

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Non-arteritic anterior ischaemic optic neuropathy (NAION): clinical features. Fully referenced neurology checklist.

Pathology

  • There is infarction of the laminar or retrolaminar part of the optic nerve head
  • This is supplied by the short posterior ciliary arteries (SPCAs)
  • The pathophysiology is not clear

Clinical features

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Systemic risk factors

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Ophthalmic risk factors

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Drug risk factors

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Risk factors for contralateral eye involvment

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Acronym

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References

  1. Atkins EJ. Nonarteritic anterior ischemic optic neuropathy. Curr Treat Options Neurol 2011; 13:92-100.
  2. Kerr NM, Chew SS, Danesh-Meyer HV. Non-arteritic anterior ischaemic optic neuropathy: a review and update. J Clin Neurosci 2009; 16:994-1000.
  3. Hayreh SS, Zimmerman MB, Podhajsky P, Alward WL. Nonarteritic anterior ischemic optic neuropathy: role of nocturnal arterial hypotension. Arch Ophthalmol 1997; 115:942-945.
  4. Foster RC, Bhatti MT, Crum OM, et al. Stroke rate, subtype, and cardiovascular risk factors in nonarteritic anterior ischemic optic neuropathy: a population-based study. J Neuroophthalmol 2020; 40:328-332. 
  5. Cestari DM, Gaier ED, Bouzika P, et al. Demographic, systemic, and ocular factors associated with nonarteritic anterior ischemic optic neuropathy. Ophthalmology 2016; 123:2446-2455. 
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