Nociplastic pain
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Nociplastic pain. This is pain that results from abnormal function of the nociceptive system. Fully referenced neurology checklist.
Pathology
- This is pain that results from abnormal function of the nociceptive system
- There is nociceptive hypersensitivity resulting from central sensitization
- There is a dull, fluctuating, widespread pain which spreads beyond the area of original pain
- Some cases may be related to TRPA1 genetic variants
Exclusion features
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Major causes
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Other causes
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Risk factors
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Differential diagnosis
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Non-drug treatments
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Drug treatments: probably effective options
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Drug treatments: ineffective options
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Synonym
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References
- Bułdyś K, Górnicki T, Kałka D, et al. What do we know about nociplastic pain? Healthcare (Basel) 2023; 11:1794.
- Popkirov S, Enax-Krumova EK, Mainka T, Hoheisel M, Hausteiner-Wiehle C. Functional pain disorders - more than nociplastic pain. NeuroRehabilitation 2020; 47:343-353.
- Schmidt H, Blechschmidt V. Nociplastic pain in research and practice: overview of biopsychosocial principles, possibilities and difficulties. Schmerz 2023; 37:242-249.
- Marchi M, Salvi E, Andelic M, et al. TRPA1 rare variants in chronic neuropathic and nociplastic pain patients. Pain 2023; 164:2048-2059.
- Fernández-de-Las-Peñas C, Nijs J, Cagnie B, et al. Myofascial pain syndrome: a nociceptive condition comorbid with neuropathic or nociplastic pain. Life (Basel) 2023; 13:694.
