Neurology landmark studies
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Neurology landmark studies. Less disability at 1 year (ISAT trial). Molyneux et al, Lancet, 2002. Fully referenced neurology checklist.
Cerebral aneurysms: coiling v clipping
- Less disability at 1 year (ISAT trial). Molyneux et al, Lancet, 2002
- Better independence at 7 years (ISAT trial first follow up). Molyneux et al, Lancet, 2005
- Less mortality at 5 years (ISAT trial second follow up). Molyneux et al, Lancet Neurol, 2009
- Less mortality at 10 years (ISAT trial third follow up). Molyneux et al, Lancet, 2015
- Nimodipine for post rupture vasospasm. Allen et al, N Engl J Med, 1983
Dementia
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Duchenne muscular dystrophy (DMD)
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Epilepsy
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Guillain Barre syndrome (GBS)
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Idiopathic intracranial hypertension (IIH)
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Infections
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Lambert Eaton myasthenic syndrome (LEMS)
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Metabolic
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Migraine: anti CGRP antibody drug trials
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Migraine: other treatment trials
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Motor neurone disease (MND)
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Movement disorders
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Multiple sclerosis (MS): steroid therapy
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Multiple sclerosis (MS): interferon beta 1a drug trials
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Multiple sclerosis (MS): interferon beta 1b drug trials
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Multiple sclerosis (MS): other disease modifying drug trials
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Myasthenia gravis (MG)
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Neuroinflammatory
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Neuromuscular
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Parkinson’s disease (PD)
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Prion diseases
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Sleep disorders
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Spinal muscular atrophy (SMA)
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Stroke: clinical
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Stroke: secondary prevention
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Stroke: management
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Stroke: thrombolysis
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Stroke: carotid endarterectomy (CEA) and stenting
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Stroke: carotid artery stenting v endarterectomy (CEA)
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Stroke: thrombectomy
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Stroke: embolic from atrial fibrillation: oral anticoagulant trials
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Stroke: embolic from unknown source: oral anticoagulant trials
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Transient global amnesia (TGA)
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Transient epileptic amnesia (TEA)
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Trigeminal autonomic cephalalgias (TAC)
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Tumours
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Vasculopathies
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References
- Molyneux A, Kerr R, Stratton I, Sandercock P, Clarke M, Shrimpton J, Holman R; International Subarachnoid Aneurysm Trial (ISAT) Collaborative Group. International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trial. Lancet. 2002; 360:1267-1274.
- Molyneux AJ, Kerr RS, Yu LM, Clarke M, Sneade M, Yarnold JA, Sandercock P; International Subarachnoid Aneurysm Trial (ISAT) Collaborative Group. International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised comparison of effects on survival, dependency, seizures, rebleeding, subgroups, and aneurysm occlusion. Lancet 2005; 366:809-817.
- Molyneux AJ, Kerr RS, Birks J, Ramzi N, Yarnold J, Sneade M, Rischmiller J; ISAT Collaborators. Risk of recurrent subarachnoid haemorrhage, death, or dependence and standardised mortality ratios after clipping or coiling of an intracranial aneurysm in the International Subarachnoid Aneurysm Trial (ISAT): long-term follow-up. Lancet Neurol 2009; 8:427-433.
- Molyneux AJ, Birks J, Clarke A, Sneade M, Kerr RS. The durability of endovascular coiling versus neurosurgical clipping of ruptured cerebral aneurysms: 18 year follow-up of the UK cohort of the International Subarachnoid Aneurysm Trial (ISAT). Lancet 2015; 385:691-697.
- Allen GS, Ahn HS, Preziosi TJ, et al. Cerebral arterial spasm-a controlled trial of nimodipine in patients with subarachnoid hemorrhage. N Engl J Med 1983; 308:619-624.
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