Narcolepsy: treatment of hypersomnia
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Narcolepsy: treatment of hypersomnia. Modafinil 50-200 mg bid: up to 300mg bid. Fully referenced neurology checklist.
First line treatments
- Modafinil 50-200 mg bid: up to 300mg bid
- Sodium oxybate 4.5g daily in two divided doses before 2.5 to 4 hours apart
- Modafinil and Sodium oxybate can be combined in severe cases
Other treatments
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Treatment of disturbed night sleep
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Investigational drugs
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References
- Wise MS, Arand DL, Auger RR, Brooks SN, Watson NF. Treatment of narcolepsy and other hypersomnias of central origin. Sleep 2007; 30:1712-1727.
- Morgenthaler TI, Kapur VK, Brown TM, et al. Practice parameters for the treatment of narcolepsy and other hypersomnias of central origin. Sleep 2007; 30:1705-1711.
- Reading P. Sleep disorders in neurology. Pract Neurol 2010; 10:300-309.
- Ropper AH, Brown RH. Principles of Neurology Eighth edition. McGraw Hill New York 2005 p348.
- Burgess CR, Scammell TE. Narcolepsy: neural mechanisms of sleepiness and cataplexy. J Neurosci 2012; 32:12305-12311.
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