Myotonic dystrophy type 1 and cancer

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Myotonic dystrophy type 1 and cancer. Older age, Earlier age at diagnosis of myotonic dystrophy. Fully referenced neurology checklist.

Risk factors for cancer

  • Older age 
  • Earlier age at diagnosis of myotonic dystrophy
  • Female gender: for benign tumours only
  • Down-regulation of miRNA-200/141
  • The risk is not associated with lifestyle risk factors
  • The risk is not familial
  • The risk is not related to CTG repeat expansion length

Most frequent reported cancers

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Other reported cancers

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References

  1. Wang Y, Pfeiffer RM, Alsaggaf R, et al. Risk of skin cancer among patients with myotonic dystrophy type 1 based on primary care physician data from the U.K. Clinical Practice Research Datalink. Int J Cancer 2017; 142:1174-1181.
  2. Win AK, Perattur PG, Pulido JS, Pulido CM, Lindor NM. Increased cancer risks in myotonic dystrophy. Mayo Clin Proc 2012; 87:130-135. 
  3. Mohamed S, Pruna L, Kaminsky P. Increasing risk of tumors in myotonic dystrophy type 1. Presse Med 2013; 42:e281-e284. 
  4. Bianchi ML, Leoncini E, Masciullo M, et al. Increased risk of tumor in DM1 is not related to exposure to common lifestyle risk factors. J Neurol 2016; 263:492-498. 
  5. Fernández-Torrón R, García-Puga M, Emparanza JI, et al. Cancer risk in DM1 is sex-related and linked to miRNA-200/141 downregulation. Neurology 2016; 87:1250-1257.
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