Muscle channelopathies: management
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Muscle channelopathies: management. Lamotrigine: this is recommended as first line, Mexiletene. Fully referenced neurology checklist.
Evidenced-treatment of myotonia
- Lamotrigine: this is recommended as first line
- Mexiletene
- Lidocaine: for myotonic crisis
Less-evidenced treatment of myotonia
Locked: subscribe to see this section.
Anaesthesia management
Locked: subscribe to see this section.
Pregnancy management
Locked: subscribe to see this section.
School management
Locked: subscribe to see this section.
Lifestyle modification
Locked: subscribe to see this section.
References
- Matthews E, Neuwirth C, Jaffer F, et al. Atypical periodic paralysis and myalgia: A novel RYR1 phenotype. Neurology 2018; 90:e412-e418.
- Matthews E, Palace J, Ramdas S, et al. Care recommendations for the investigation and management of children with skeletal muscle channelopathies. Pediatr Neurol 2023; 145:102-111.
- Andersen G, Hedermann G, Witting N, Duno M, Andersen H, Vissing J. The antimyotonic effect of lamotrigine in non-dystrophic myotonias: a double-blind randomized study. Brain 2017; 140:2295-2305.
- Statland JM, Bundy BN, Wang Y, et al; Consortium for Clinical Investigation of Neurologic Channelopathies. Mexiletine for symptoms and signs of myotonia in nondystrophic myotonia: a randomized controlled trial. JAMA 2012; 308:1357-1365.
